How can somthing so little cause something so big????

Above is a picture of leishmaniasis - visceral leishmaniasis is one of the causes of massive splenomegaly which can be distinguished from the listed causes of splenomegaly below by the fact that they are highlighted RED

Hematologic
Lymphoma, usually indolent variants
Acute and chronic leukemias (CML)
Polycythemia vera

Myelofibrosis
Multiple myeloma
Essential thrombocythemia
Acute and chronic hemolytic anemias (thalassemia)
Sickle cell diseas

Malignancy
Hematologic (see above)
Primary splenic tumors
Metastatic solid tumors

Infection
Viral - hepatitis, infectious mononucleosis, cytomegalovirus
Bacterial - salmonella, brucella, tuberculosis (MAC )
Parasitic - malaria, schistosomiasis,toxoplasmosis, leishmaniasis (Kala-azar)
Infective endocarditis
Fungal

Collagen Vascular Disease
Sarcoid
Systemic lupus erythematosus
Rheumatoid arthritis (Felty syndrome)


Infiltrative
Malignancy (infiltrative, primary tumor, metastatic tumor)
Gaucher's disease
Niemann-Pick disease
Amyloid
Glycogen storage disease
Langerhans cell histiocytosis
Hemophagocytic lymphohistiocytosis


Congestive
Cirrhosis
Heart failure

Thrombosis of portal, hepatic, or splenic veins