Panhypopituitarism

Today we discussed an a case of hyponatremia that eventually led to the diagnosis of panhypopituitarism.

This can be a very difficult diagnosis to make due to the non-specific symptoms that a patient complains of (as was seen here).

Etiologies incluede;
1) Brain Damage (Traumatic, radiation, SAH, CVA, Surgery)
2) Neoplastic (originating in the pituitary or compression from outside)
3) Infectious
4) Infarction (Sheehan's, apoplexy)
5) Autoimmune
6) Infiltrative (hemochromatosis, histiocytosis)
7) Congenital

Here is a recent review from Lancet that highlights diagnosis and management.