Hypokalemic Periodic Paralysis
rare disorder of unknown cause that presents as episodic episodes of muscle weakness or paralysis.
it is thought to be associated with events that increase catecholamine and / or insulin including exercise, stress and carbohydrate loads
HPP may be familial or associated with thyrotoxcosis
HPP due to thyrotoxicosis is often see in young Asian males
pathogenesis is thought to be a calcium receptor mutation
TREATMENT:
acute: administration of 60-110meQ KCL can often abort acute attacks
(avoid administration in glucose containing solutions so as not to precipitate an insulin surge and worsening symptoms)
chronic: treat thyrotoxicosis or with BB in familial formsappropriately counsel the patient to avoid triggers!
