RS3PE SYNDROME

RS3PE syndrome stands for remitting seronegative symmetrical synovitis with pitting edema.

This syndrome has many similar features to PMR. Patienst are often over the age of 50 and are seronegative. However, unlike PMR, many patients with RS3PE have sudden onset of polyarthritis, usually more prominent distally.

Patients with this disorder respond to low-dose glucocorticoids.

RS3PE also has been described as a paraneoplastic disorder that is associated with solid tumors and hematologic disorders.

Here is a good review article on PMR.

* Areas of pain in PMR