Today in morning report we had a quick discussion on the use of fluoroquinolones. Here are some pearls to consider prior to prescribing a fluoroquinolone:
- Sensitivity to UV: wear sun protection!
- Prolongation of QT interval: Check baseline ECG and repeat ECG while on medication if baseline QTc is prolonged
- Tendonopathy and tendon rupture: worse in elderly >60yrs, mainly Achilles tendon
- Rash: Immediate IgE mediated reactions and delayed type hypersensitivity reactions (maculopapular rash)
- Hepatic toxicity: may cause transaminitis and rarely acute liver injury
- Hypoglycemia: mainly seen with gatifloxacin
- Exacerbation of myasthenia gravis
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