Thursday, March 7, 2013

Use of Fluoroquinolones



Today in morning report we had a quick discussion on the use of fluoroquinolones. Here are some pearls to consider prior to prescribing a fluoroquinolone:

  • Sensitivity to UV: wear sun protection!
  • Prolongation of QT interval: Check baseline ECG and repeat ECG while on medication if baseline QTc is prolonged
  • Tendonopathy and tendon rupture: worse in elderly >60yrs, mainly Achilles tendon
  • Rash: Immediate IgE mediated reactions and delayed type hypersensitivity reactions (maculopapular rash)
  • Hepatic toxicity: may cause transaminitis and rarely acute liver injury
  • Hypoglycemia: mainly seen with gatifloxacin
  • Exacerbation of myasthenia gravis

No comments :