Today we discussed some issues about Nephrotic Syndrome. Here are some thoughts....
What is it? proteinuria (albuminuria greater than 3 g per 24 hours), hypoalbuminemia, and peripheral edema. Patients also have a predilection for hyperlipidemia and thrombotic disease.
Etiology: diabetes mellitus, systemic lupus erythematosus, and then primary or secondary minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy and amyloidosis.
A brief word about some of these:
Minimal change disease: more common in children. Also seen in Hodgkin's Disease or with NSAID use.
What is it? proteinuria (albuminuria greater than 3 g per 24 hours), hypoalbuminemia, and peripheral edema. Patients also have a predilection for hyperlipidemia and thrombotic disease.
Etiology: diabetes mellitus, systemic lupus erythematosus, and then primary or secondary minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy and amyloidosis.
A brief word about some of these:
Minimal change disease: more common in children. Also seen in Hodgkin's Disease or with NSAID use.
Focal Segmental Glomerulosclerosis: more common in those of African descent. Can be seen with HIV, reflux nephropathy, NSAID use, or obesity.
Membranous nephropathy: often associated with underlying hepatitis B, solid and hematologic malignancies, autoimmune disease, and medications.
See you on the wards,
Isaac
