HoPingKong-isms:
1. "the knee bone is connected to the hip bone, the hip bone is connected to the diaphragm": referring to the progression of Guillain-Barré syndrome where weakness can sometimes ascend to respiratory muscles.
1. "the knee bone is connected to the hip bone, the hip bone is connected to the diaphragm": referring to the progression of Guillain-Barré syndrome where weakness can sometimes ascend to respiratory muscles.
2. "You are only half right": referring to to the Brown-Séquard syndrome - a lateral hemisection of the spinal cord.
3. "I'm a little sad today, and a little cocky": referring to Coxsackie viral infections which can cause pericarditis
Guillain-Barré syndrome:
This is really an umbrella term that encompasses a few related syndromes which are immune-related polyneuropathies. Classically, patients present with bilateral ascending weakness and decreased deep tendon reflexes. Many patients will also have a sensory component (eg. numbness), and autonomic dysfunction as well (eg. tachycardia, hyper/hypotension, urinary retention). One of the major risks is when respiratory muscle function is depressed - patients need ventilatory support in the intensive care unit.
The diagnosis can be confirmed with nerve conduction studies and cerebral spinal fluid analysis. An albuminocytologic dissociation may be seen in the CSF about a week after symptoms start, which shows a normal WBC count but elevated protein.
See the below link for a great BMJ review article: http://www.bmj.com/cgi/content/full/337/jul17_1/a671
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