Miller Fisher Syndrome

Guillain-Barré syndrome (GBS) is an immune-mediated polyneuropathy characterized classically by ascending weakness and absent reflexes. GBS is a heterogeneous disease with several variants. Miller Fisher Syndrome (MFS) is a variant that presents with opthalmoplegia, ataxia and areflexia.

In patients with GBS, CSF has elevated protein and normal WBC. In about 85% of patients with MFS antibodies against GQ1b (a ganglioside component of nerve) is positive, though this testing is not routinely performed.

Here is review of Guillain-Barre Syndrome.

* Dr. C. Miller Fisher, Canadian neurologist who first described the MFS variant of GBS in 1956. He was a stroke neurologist who contributed greatly to our understanding of lacunar stroke, and strokes related to atrial fibrillation.