Wednesday, October 12, 2011

Paraneoplastic Erythrocytosis


There are 5 types of tumor commonly associated with the overproduction Epo:

1. Hepatocellular carcinoma: Epo elevation doesn’t always cause erythropoiesis because of RBC production inhibition by malignancy.

2. Renal cell carcinoma: In about 1-5% of patients.

3. Hemangioblastoma

4. Pheochromocytoma

5. Uterine myomata: clue will be absence of anemia in patients with menorrhagia. RBC overproduction is reversed following myomectomy.

*Contrast-enhanced MRI image of a patient with Hb=194, showing renal cell carcinoma(arrow).

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