SSRI and SIADH

This morning we talked about the association between SSRIs and SIADH.

The article we talked about was a review, by Dr. Liu, of case reports involving various SSRIs and hyponatremia. This study found that the majority (83%) of patients with this complication were over the age of 65. The average time to onset of hyponatremia was 13 days (range 3 to 120 days). This finding has since been confirmed through a prospective study.

Take home message is that elderly patients are at increased risk of hyponatremia associated with SSRIs.

Here is the abstract for the above article.

Here is a great review article about SAIDH.